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Amiodarone finds its place amongst the drugs with the longest half-life. It can take even 107 days(!) for our body to get rid of only half of a dose we’ve taken. It can take even 107 days(!) for our body to get rid of only half of a dose we’ve taken. Appropriate Use. restrict use to indicated life-threatening arrhythmias due to drug-assoc. if possible, do not initiate fexinidazole until 5 half-lives after AMIODARONE. MURPHY AND WILKOFF C3. TABLE 1. Incidence of amiodarone- induced side effects. Amiodarone’s elimination half-life is long and variable. SYSTEM AND sekgem 200 by M Srinivasan 2024 Cited by 12The principal active metabolite, desethylamiodarone, is reported to have a half-life of 60–90 days in chronic oral dosing. Most of the drug is The amiodarone that he was on has basically wiped out his thyroid. I’ve made life style changes but probably too late. I am very scared According to the prescribing information for amiodarone, the average apparent plasma terminal elimination half-life of amiodarone is of 58 days (ranging from 15 to 142 days). The terminal half-life range was between 14 to 75 days for the active metabolite, (DEA). by TJ Campbell 2024 Cited by 6It also has a half-life of approximately 50 days, so it can take weeks for therapeutic effects to appear. While amiodarone has many
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